代表性教学科研项目: 1、 国家自然科学基金青年基金,2019/01-2021/12,主持。 2、 山东省自然科学基金面上项目,2024/01-2026/12,主持。 3、 山东省高等学校青年创新团队项目(团队带头人),2024/12-2027/12,主持。 4、 国家留学基金委CSC公派留学项目,2024/09-2025/09,主持。 5、 教育部产学合作协同育人项目,2021/04-2023/03,主持。 6、 青岛市博士后应用研究项目,2020/8-2022/07,主持。 代表性论文: [1] Z. Yuan, H. Chai*, Y. Huang, Z. Zhang, W. Tan, Y. Sun, J. Ma, G. Zhang*, Porphyrin-engineered metal−organic frameworks for photo/electrochemical sensing: Preparation and mechanisms, Coord. Chem. Rev. 2025, 527, 216385. [2] H. Chai, Y. Li, K. Yu, Z. Yuan, J. Guan, W. Tan, J. Ma, X. Zhang, G. Zhang*, Two-Site Enhanced Porphyrinic Metal–Organic Framework Nanozymes and Nano-/Bioenzyme Confined Catalysis for Colorimetric/Chemiluminescent Dual-Mode Visual Biosensing, Anal. Chem. 2023, 95, 16383-16391. [3] H. Chai, K. Yu, Y. Zhao, Z. Zhang, S. Wang, C. Huang, X. Zhang, G. Zhang*, MOF-On-MOF Dual Enzyme-Mimic Nanozyme with Enhanced Cascade Catalysis for Colorimetric/Chemiluminescent Dual-Mode Aptasensing, Anal. Chem. 2023, 95, 10785-10794. [4] G. Y. Zhang*, H. Chai, M. W. Tian, S. F. Zhu, L. J. Qu, X. J. Zhang*, Zirconium-Metalloporphyrin Frameworks-Luminol Competitive Electrochemiluminescence for Ratiometric Detection of Polynucleotide Kinase Activity, Anal. Chem. 2020, 92, 7354. [5] H. Sun, J. Guan, H. Chai*, K. Yu, L. Qu, X. Zhang, G. Zhang*, Zinc porphyrin/MXene hybrids with phosphate-induced stimuli-responsive behavior for dual-mode fluorescent/electrochemiluminescent ratiometric biosensing, Biosens. Bioelectron. 2024, 251, 116080. [6] Y. Li, H. Chai * , Z. Yuan, C. Huang, S. Wang, Y. Sun, X. Zhang, G. Zhang*, Metal–organic framework-engineered enzyme/nanozyme composites: Preparation, functionality, and sensing mechanisms, Chem. Eng. J. 2024, 496, 153884. [7] K. Yu, H. Chai *, H. Sun, X. Xiang, H. Zhao, M. Tian, L. Qu, G. Zhang*, X. Zhang*, A fluorescence analysis model for assessing the water stability of porphyrinic metal–organic frameworks, Sens. Actuators B Chem. 2024, 401, 135046. [8] G. Zhang, Y. Ma, H. Chai*, K. Yu, Y. Li, S. Wang, J. Ma, L. Qu, W. Tan*, X. Zhang, Porphyrinic metal–organic framework@alumina nanocomposite fluorescent probe: Two-stage stimuli-responsive behavior and phosphate sensing, Sens. Actuators B Chem. 2022, 370, 132395. [9] Z. Zhang, Y. Li, Z. Yuan, L. Wu, J. Ma, W. Tan, Y. Sun, G. Zhang*, H. Chai*, MOF nanozymes: active sites and sensing applications, Inorg. Chem. Front. 2025, 12, 400-429. [10] H. Sun, H. Chai*, Z. Yuan, K. Yu, L. Qu, X. Zhang, G. Zhang*, Dual-mode visual fluorescent/colorimetric ratio sensing of alkaline phosphatase in milk based on porphyrinic MOF photonanozyme fibers, Food Chem. 2025, 475, 143289. [11] Y. Li, H. Chai*, Z. Yuan, Z. Zhang, Y. Zhao, K. Yu, Y. Sun, G. Zhang*, Zeolitic imidazolate framework-encapsulated zinc porphyrin photoresponsive nanozyme for colorimetric/fluorescent dual-mode sensing of glyphosate, Talanta, 2024, 276, 126253. [12] G. Zhang*, K. Yu, B. Zhou, J. Wang, C. Zheng, L. Qu, H. Chai*, X. Zhang, Magnetic zirconium-based Prussian blue analog nanozyme: Enhanced peroxidase-mimicking activity and colorimetric sensing of phosphate ion, Microchim. Acta, 2022, 189, 220. [13] H. Chai, Y. Ma, Z. Yuan, Y. Li, G. Liu, L. Chen, Y. Tian, W. Tan, J. Ma, G. Zhang*, A ratiometric fluorescence sensor based on carbon dots and two-dimensional porphyrinic MOFs for on-site monitoring of sulfide, Microchem. J. 2023, 185, 108288. [14] G. Y. Zhang*, M. J. Li, K. Yu, H. Chai*, S. H. Xu, T. L. Xu, L. J. Qu, X. J. Zhang*, Two-Dimensional Metalloporphyrinic Framework Nanosheet-Based Dual-Mechanism-Driven Ratiometric Electrochemiluminescent Biosensing of Protein Kinase Activity, ACS Appl. Bio Mater. 2021, 4, 161. [15] M. Li, G. Zhang*, A. Boakye, H. Chai*, L. Qu*, X. Zhang, Recent Advances in Metal-Organic Framework-Based Electrochemical Biosensing Applications, Front. Bioeng. Biotechnol. 9 (2021), 797067. |