代表性教学科研项目: 1、 山东省高等学校青年创新团队项目(团队带头人),2025/1-2027/12,主持。 2、 国家自然科学基金青年基金,2019/01-2021/12,主持。 3、 山东省自然科学基金面上项目,2025/10-2028/9,主持。 4、 山东省自然科学基金面上项目,2024/01-2026/12,主持。 5、 国家留学基金委CSC公派留学项目,2024/09-2025/08,主持。 6、 教育部产学合作协同育人项目,2021/04-2023/03,主持。 7、 青岛市博士后应用研究项目,2020/8-2022/07,主持。 代表性论文: (1) Y. Huang, X. Sun, Z. Zhang, C. Huang, L. Wu, W. Tan, H. Chai*, G. Zhang*, Metal–organic framework-based dual-mode biosensors: Mechanisms and applications. Coord. Chem. Rev. 2025, 545, 217006. (2) Z. Yuan, H. Chai*, Y. Huang, Z. Zhang, W. Tan, Y. Sun, J. Ma, G. Zhang*, Porphyrin-engineered metal−organic frameworks for photo/electrochemical sensing: Preparation and mechanisms, Coord. Chem. Rev. 2025, 527, 216385. (3) H. Chai*, X. Sun, X. Tan, Z. Yuan, J. Guan, X. Zhang, J. Xie*, G. Zhang*, Electrochemical Gating of d-Band Engineering in Hierarchically Bridged Dual-Site Nanozymes for Synergistic Cascade Catalysis and Wearable Biosensing. Anal. Chem. 2026, 98, 3919–3933. (4) H. Chai, Y. Li, K. Yu, Z. Yuan, J. Guan, W. Tan, J. Ma, X. Zhang, G. Zhang*, Two-Site Enhanced Porphyrinic Metal–Organic Framework Nanozymes and Nano-/Bioenzyme Confined Catalysis for Colorimetric/Chemiluminescent Dual-Mode Visual Biosensing, Anal. Chem. 2023, 95, 16383-16391. (5) H. Chai, K. Yu, Y. Zhao, Z. Zhang, S. Wang, C. Huang, X. Zhang, G. Zhang*, MOF-On-MOF Dual Enzyme-Mimic Nanozyme with Enhanced Cascade Catalysis for Colorimetric/Chemiluminescent Dual-Mode Aptasensing, Anal. Chem. 2023, 95, 10785-10794. (ESI高被引) (6) G. Y. Zhang*, H. Chai, M. W. Tian, S. F. Zhu, L. J. Qu, X. J. Zhang*, Zirconium-Metalloporphyrin Frameworks-Luminol Competitive Electrochemiluminescence for Ratiometric Detection of Polynucleotide Kinase Activity, Anal. Chem. 2020, 92, 7354. (7) H. Sun, J. Guan, H. Chai*, K. Yu, L. Qu, X. Zhang, G. Zhang*, Zinc porphyrin/MXene hybrids with phosphate-induced stimuli-responsive behavior for dual-mode fluorescent/electrochemiluminescent ratiometric biosensing, Biosens. Bioelectron. 2024, 251, 116080. (ESI高被引) (8) X. Sun, J. Cui, X. Tan, Z. Zhen, W. Tan, X. Ga, K. Yu*, G. Li*, H. Chai*, G. Zhang*, Bimetallic Nanozymes: Structure-Activity, Regulatory Strategies, and Adaptive Applications. Small 2026, 22, e10317. (9) Y. Li, H. Chai * , Z. Yuan, C. Huang, S. Wang, Y. Sun, X. Zhang, G. Zhang*, Metal–organic framework-engineered enzyme/nanozyme composites: Preparation, functionality, and sensing mechanisms, Chem. Eng. J. 2024, 496, 153884. (ESI高被引) (10) K. Yu, H. Chai *, H. Sun, X. Xiang, H. Zhao, M. Tian, L. Qu, G. Zhang*, X. Zhang*, A fluorescence analysis model for assessing the water stability of porphyrinic metal–organic frameworks, Sens. Actuators B Chem. 2024, 401, 135046. (11) G. Zhang, Y. Ma, H. Chai*, K. Yu, Y. Li, S. Wang, J. Ma, L. Qu, W. Tan*, X. Zhang, Porphyrinic metal–organic framework@alumina nanocomposite fluorescent probe: Two-stage stimuli-responsive behavior and phosphate sensing, Sens. Actuators B Chem. 2022, 370, 132395. (12) Z. Zhang, Y. Li, Z. Yuan, L. Wu, J. Ma, W. Tan, Y. Sun, G. Zhang*, H. Chai*, MOF nanozymes: active sites and sensing applications, Inorg. Chem. Front. 2025, 12, 400-429. (13) H. Sun, H. Chai*, Z. Yuan, K. Yu, L. Qu, X. Zhang, G. Zhang*, Dual-mode visual fluorescent/colorimetric ratio sensing of alkaline phosphatase in milk based on porphyrinic MOF photonanozyme fibers, Food Chem. 2025, 475, 143289. (ESI高被引) (14) Y. Li, H. Chai*, Z. Yuan, Z. Zhang, Y. Zhao, K. Yu, Y. Sun, G. Zhang*, Zeolitic imidazolate framework-encapsulated zinc porphyrin photoresponsive nanozyme for colorimetric/fluorescent dual-mode sensing of glyphosate, Talanta, 2024, 276, 126253. (15) G. Zhang*, K. Yu, B. Zhou, J. Wang, C. Zheng, L. Qu, H. Chai*, X. Zhang, Magnetic zirconium-based Prussian blue analog nanozyme: Enhanced peroxidase-mimicking activity and colorimetric sensing of phosphate ion, Microchim. Acta, 2022, 189, 220. (16) H. Chai, Y. Ma, Z. Yuan, Y. Li, G. Liu, L. Chen, Y. Tian, W. Tan, J. Ma, G. Zhang*, A ratiometric fluorescence sensor based on carbon dots and two-dimensional porphyrinic MOFs for on-site monitoring of sulfide, Microchem. J. 2023, 185, 108288. (17) G. Y. Zhang*, M. J. Li, K. Yu, H. Chai*, S. H. Xu, T. L. Xu, L. J. Qu, X. J. Zhang*, Two-Dimensional Metalloporphyrinic Framework Nanosheet-Based Dual-Mechanism-Driven Ratiometric Electrochemiluminescent Biosensing of Protein Kinase Activity, ACS Appl. Bio Mater. 2021, 4, 161. (18) M. Li, G. Zhang*, A. Boakye, H. Chai*, L. Qu*, X. Zhang, Recent Advances in Metal-Organic Framework-Based Electrochemical Biosensing Applications, Front. Bioeng. Biotechnol. 9 (2021), 797067. |